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Mimecast 451: Internal resources temporarily unavailable

451 Internal resources are temporarily unavailableMimecast temporary internal failureTemporary: the sender retriesFrom Mimecast

Example
451 Internal resources are temporarily unavailable

What it means

A 451 is a temporary failure under RFC 5321: the receiving side asks the client to try again later, so your server keeps the message and retries. Mimecast’s published SMTP error reference gives two reasons for this reply: greylisting, or the reputation of the sending IP address.

Greylisting is a deliberate first refusal. Mimecast defers the first attempt from a sender it has not seen recently and accepts the retry after a short wait, because legitimate servers retry and many spam tools do not. A deferral that clears on the next attempt or two is greylisting doing its job.

The reputation case is about your sending IP. When Mimecast sees a poor reputation for the address, it keeps deferring instead of accepting, and retries alone may not get through. If the deferral repeats for hours across several Mimecast customers, look at your IP and domain reputation rather than waiting.

Likely causes

  • Greylisting: the first message from your server to this Mimecast customer in a while, deferred until your server retries.
  • Your sending IP has a poor reputation, for example a listing on a public blocklist, missing reverse DNS, or a history of spam or bounces.
  • Your server retries too quickly or from a different IP each time (a pool), so greylisting never sees the same sender come back.

How to fix it

  1. Let your server retry. A greylisting deferral normally clears on the next attempt; check your queue to confirm the message is deferred, not bounced.
  2. If you send from a pool of IPs, make retries come from the same IP, or ask the recipient to permit your sending range, so greylisting can recognise the retry.
  3. If deferrals continue for hours, check your sending IP against blocklists and confirm reverse DNS, SPF, DKIM, and DMARC are in place.
  4. Fix any listing or authentication gap, then let the queue retry. Ask the recipient to add your IP to their Mimecast permitted senders if mail is urgent.

Checks that apply

  • Blacklist Check Shows whether your sending IP is listed anywhere, the usual sign of the reputation case.
  • Reverse DNS (PTR) Confirms your sending IP has reverse DNS that matches its name, a basic reputation signal.
  • MX Lookup Shows which Mimecast region hosts the recipient, useful when you compare with other recipients.
See the example diagnosed

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FAQ

Do I need to resend?
Not while the message is still queued. Your server retries a 451 on its own, and a greylisting deferral usually clears on the next attempt.
How do I tell greylisting from a reputation problem?
Greylisting clears after a retry or two. If the same deferral repeats for hours, especially at several Mimecast customers, your sending IP reputation is the likely cause.

Sources:Policies: Mimecast SMTP Error Codes (Mimecast Support)Checked 2026-10-18

All 191 bounce codes